Clinical Trial Tested Safety of Potential New Drug to Manage Endometriosis
The non-peptide gonadotropin-releasing hormone antagonist SHR7280 has favorable safety, pharmacokinetics, and pharmacodynamics in 3 different doses, according to the results of a phase 1 clinical trial published in the scientific journal Clinical Pharmacokinetics. “The results of this study provide evidence to…
Key Points Lay SummaryCombined Birth Control Pills May Be Beneficial in Reducing Endometriosis Pain
Treatment with an extended regimen of ethinylestradiol and drospirenone improves health-related quality of life, according to a new study conducted on Japanese women with painful periods or pelvic pain due to endometriosis. (Ethinylestradiol and drospirenone are medications that are widely…
Key Points Lay SummaryMindfullness Can Hep Reduce Endometriosis Pain
A brief mindfulness-based intervention can be useful in managing pain related to endometriosis and restoring patients’ psychological well-being, found a new study published in the European Journal of Pain. This finding contributes to the applicability of mindfulness-based interventions in people…
Key Points Lay SummaryA trial of exogenous melatonin on dysmenorrhea in women "without endometriosis"
In their recent article published in “European Journal of Clinical Pharmacology”, Dr. Söderman and associates from Stockholm report the results of their randomized, double-blind, placebo-controlled trial on the effects of oral melatonin in women with dysmenorrhea -unrelated to endometriosis-. Melatonin is a hormone…
Key Points Lay SummaryNew Endometriosis Clinical Trial Now Recruiting Participants
A new clinical trial investigating the effect of cognitive-behavioral therapy on quality of life in patients undergoing surgery for endometriosis is now recruiting participants. The randomized, controlled trial aims to recruit 100 participants, ages 18 to 50 with proven endometriosis…
Key Points Lay SummaryInflammatory and genetical background of endometriosis may yield new therapeutic approaches
Elisa Giacomini and colleagues from medical centers in Milan, Italy have published their review manuscript on the inflammatory and genetical pathogenetic background of endometriosis in a recent issue of “International Journal of Molecular Sciences”, suggesting also new therapeutic approaches. The inflammatory…
Key Points Lay SummaryNon-hormonal chemicals for endometriosis related pain reduction
Loi and colleagues conducted a clinical prospective study at the Department of Obstetrics and Gynecology, University of Cagliari, Italy, and published in the journal "International Journal of Women’s Health". Formation of adhesions and/or interference with the reproductive process endometriosis, severe…
Key Points Lay SummaryClinical trial for the use of oral lactobacillus on endometriosis pain severity
The standard treatment of endometriosis consists of surgery and hormonal based treatment. There is evidence for the efficacy of these types of treatment, although their side effects remain a critical consideration for women. Based on molecular studies, changes in the…
Key Points Lay SummaryEfficacy of an antibiotic, clarithromycin for endometriosis
Laparoscopic surgery is the standard treatment for advanced stages of endometriosis, followed by postoperative modalities including to progesterone, antiprogestogens, estrogen-progesterone combinations, danazol, and gonadotropin-releasing hormone agonists to reduce recurrence after surgery. However, these drugs interfere with ovulation and fertility. The…
Key Points Lay SummaryFactors Affecting Women’s Choices to Enter Clinical Trials
Women were strongly influenced by their previous experiences and personal circumstances when deciding to take part in a clinical trial. This is based on the findings of a study published in the journal Pilot and Feasibility Studies that explored the…
Key Points Lay SummaryFurther Results From the FEELING Study Published
Some women are more likely to develop deep infiltrating endometriosis according to the further analysis of the results of the FEELING study. These are women who: are married, are older, have siblings, have had a prior pregnancy, or for whom…
Key Points Lay SummaryThe use of Elagolix in Women with Liver and Kidney Impairments
Elagolix may be used in women with moderate liver impairment, when necessary, for up to six months at a dose of 150 mg a day, according to a study published in the scientific journal Clinical Pharmacology in Drug Development. The…
Key Points Lay SummaryIVF Is the Best Option to Become Pregnant for Women with Severe Endometriosis, or Is It Not?
Treating rectal endometriosis with surgery seems to increase the chance of a woman conceiving, with most pregnancies occurring naturally. This is according to a study published in the medical journal Human Reproduction. The optimal treatment for women with severe endometriosis…
Key Points Lay SummaryFDA Approves Endometriosis Pain Treatment
The U.S. Food and Drug Administration (FDA) approved a new medication for the treatment of moderate to severe pain associated with endometriosis, making it the first treatment to be approved in 10 years. The decision was announced in the Journal…
Key Points Lay SummaryN-acetyl cysteine, alpha lipoic acid and bromelain improved endometriosis-associated pelvic pain
Oxidative stress has been implicated in many processes that lead to the development and progression of endometriosis. Typically, women with endometriosis have to endure pelvic pain which negatively impacts their quality of life. Pelvic pain can be chronic and related…
Key Points Lay SummaryTreatment of Endometriosis in Adolescents
Most women with endometriosis who have been treated with Lupron plus add back as adolescents felt the treatment was effective in reducing the pain caused by the condition, according to a study published in the Journal of Pediatric & Adolescent…
Key Points Lay Summary"New Pain Dairy" Could Help Better Evaluate the Impact of Endometriosis on Women’s Daily Lives
Researchers developed a new patient-reported endometriosis pain daily diary. The diary can help evaluate endometriosis-related pain and the impacts this can have on patients' lives as well as be used in clinical trials to assess patients’ response to treatment. “The…
Key Points Lay SummaryElagolix (ABT-620) for endometriosis pain?
Elagolix is an orally active gonadotropin-releasing hormone antagonist that has just recently completed Phase 3 clinical trial for endometriosis-associated pain (NCT01931670). The review article by Alessandro et al in Archives of Gynecology and Obstetrics summarized the current research findings on…
Key Points Lay Summary